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The cytochrome <i>P</i> 450 <i>CYP1A2</i> genetic polymorphisms * <i>1F</i> and * <i>1D</i> do not affect clozapine clearance in a group of schizophrenic patients

1 May 2005

Abstract excerpt

BACKGROUND: The atypical antipsychotic drug clozapine is metabolized by CYP1A2. The activity of CYP1A2 is highly variable and is among others dependent on smoking habits. Certain genotypes of CYP1A2 have been associated with increased inducibility/activity of CYP1A2. However, the relevance of genotyping for these mutations in a clinical setting has not yet been demonstrated. METHODS: In this study, the CYP1A2...

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PMID: 15949157
DOI: 10.1258/0004563053857798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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