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Article

Nonresponse to clozapine and ultrarapid CYP1A2 activity: clinical data and analysis of CYP1A2 gene.

Journal of clinical psychopharmacology - 1 Apr 2004

Eap Chin B, Bender Stefan, Jaquenoud Sirot E, Cucchia Gianni, Jonzier-Perey Michèle, Baumann Pierre, Allorge Delphine, Broly Franck

Abstract excerpt

Clozapine (CLO), an atypical antipsychotic, depends mainly on cytochrome P450 1A2 (CYP1A2) for its metabolic clearance. Four patients treated with CLO, who were smokers, were nonresponders and had low plasma levels while receiving usual doses. Their plasma levels to dose ratios of CLO (median; range, 0.34; 0.22 to 0.40 ng x day/mL x mg) were significantly lower than ratios calculated from another study with 29...

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Source

Identifiers

PMID: 15206669
DOI: 10.1097/01.jcp.0000116646.91923.2f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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