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The Potential Role of POR28 and CYP1A2F Genetic Variations and Lifestyle Factors on Clozapine and N-DesmethylClozapine Plasma Levels in Schizophrenia Patients.

Expert opinion on drug metabolism & toxicology - 1 Jan 2000

Demirbugen Oz Merve, Ozdemir Fezile, Tok Kenan Can, Dural Emrah, Kir Yagmur, Ulusoy Muge, Gumustas Mehmet, Baskak Bora, Suzen H Sinan

Abstract excerpt

BACKGROUND: Despite its advantages over other antipsychotics, for treatment-resistant schizophrenia, clinical use of Clozapine (CLZ) is challenging by its narrow therapeutic index and potentially life-threatening dose-related adverse effects. RESEARCH DESIGN AND METHODS: As the potential role in CLZ metabolism is assigned to CYP1A2 enzyme and consequently Cytochrome P450 oxidoreductase (POR) their genetic...

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PMID: 37269349
DOI: 10.1080/17425255.2023.2221849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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