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Article

The effect of tandem substitutions on the correlation between synonymous and nonsynonymous rates in rodents.

Genetics - 1 Nov 1999

Smith N G, Hurst L D

Abstract excerpt

Nonsynonymous substitutions in DNA cause amino acid substitutions while synonymous substitutions in DNA leave amino acids unchanged. The cause of the correlation between the substitution rates at nonsynonymous (K(A)) and synonymous (K(S)) sites in mammals is a contentious issue, and one that impacts on many aspects of molecular evolution. Here we use a large set of orthologous mammalian genes to investigate the...

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Identifiers

PMID: 10545467
DOI: 10.1093/genetics/153.3.1395
PMCID: PMC1460828

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