Article
Identification of exon sequences and an exon binding protein involved in alternative RNA splicing of calcitonin/CGRP.
Nucleic acids research - 11 May 1992
Cote G J, Stolow D T, Peleg S, Berget S M, Gagel R F
Abstract excerpt
Transcripts derived from the 6 exon CALC I gene are differentially processed in a tissue-specific fashion to include or exclude a calcitonin-specific exon 4. All cell types which transcribe a second calcitonin/CGRP gene, CALC II, exclude exon 4. Substitution of the first 30 nucleotides of CALC I exon 4 with analogous CALC II sequence was sufficient to prevent recognition of exon 4 in in vitro or in vivo RNA...
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