Article
Loss of calcitonin binding in rat is not related to calcitonin receptor gene abnormality.
Biochemical and biophysical research communications - 29 Jun 2001
Nakamura M, Yang Q, Gouda T, Takehara A, Ohta H, Miyajima M, Kakudo K
Abstract excerpt
C-cell tumors occur frequently (50%) in old WAG/Rij rats. Interestingly, genetically transmitted loss of CT binding sites in the kidney has also been demonstrated in WAG/Rij rats. To determine if these issues are resulted from mutation of calcitonin receptor (CTR), we analyzed the CTR genomic abnormality in WAG/Rij rat. We demonstrated that both Wistar and WAG/Rij rats expressed type-C1a CTR by RT-PCR analysis...
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