Article
Identification of attenuated variants of HIV-1 circulating recombinant form 01_AE that are associated with slow disease progression due to gross genetic alterations in the nef/long terminal repeat sequences.
The Journal of infectious diseases - 1 Jul 2005
Kondo Makiko, Shima Takako, Nishizawa Masako, Sudo Koji, Iwamuro Shinya, Okabe Takeshi, Takebe Yutaka, Imai Mitsunobu
Abstract excerpt
We identified an unusual case of human immunodeficiency virus type 1 (HIV-1) infection in a patient (GM43) who exhibited a persistently low antibody response and undetectable viral load during a 5-year follow-up period. GM43 harbored HIV-1 circulating recombinant form 01_AE with gross deletions in the nef/long terminal repeat (LTR) region. The sizes of the deletions increased progressively from 84 to >400 bp...
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