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CHEK2 Alterations in Pediatric Malignancy: A Single-Institution Experience

8 Mar 2023

Abstract excerpt

Background: Approximately 10% of pediatric malignancies are secondary to germline alterations in cancer-predisposing genes. Checkpoint kinase 2 (CHEK2) germline loss-of-function variants have been reported in pediatric cancer patients, but clinical phenotypes and outcomes are poorly described. We present our single-institution experience of pediatric oncology patients with CHEK2 germline alterations, including...

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PMID: 36980535
DOI: 10.3390/cancers15061649

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