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Article

Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury.

Circulation research - 18 Feb 2000

Yoshida T, Maulik N, Engelman R M, Ho Y S, Das D K

Abstract excerpt

The role of Cu/Zn-superoxide dismutase (SOD) in myocardial ischemic reperfusion injury was studied by using a mouse model with targeted disruption of the mouse Sod I gene. Inactivation of the functional mouse Sod I gene in hearts by gene targeting (Sod I(+/-)) resulted in a 50% reduction of Cu/Zn-SOD mRNA and significant reduction of Cu/Zn-SOD enzyme activity compared with that of wild-type Sod I(+/+) mice....

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Identifiers

PMID: 10679476
DOI: 10.1161/01.res.86.3.264

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