Article
Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease.
Dementia and geriatric cognitive disorders - 1 Jan 2004
McCaddon Andrew, Blennow Kaj, Hudson Peter, Hughes Alan, Barber Joan, Gray Rob, Davies Gareth, Williams John H H, Duguid Jennifer, Lloyd Alwyn, Tandy Steve, Everall Marge, Cattell Howard, McCaddon Anne, Ellis Dick, Palmer Mona, Bogdanovic Nenad, Gottfries Carl-Gerhard, Zetterberg Henrik, Rymo Lars, Regland Björn
Abstract excerpt
Isoforms of the vitamin B(12) carrier protein transcobalamin (TC) might influence its cellular availability and contribute to the association between disrupted single-carbon metabolism and Alzheimer's disease (AD). We therefore investigated the relationships between the TC 776C>G (Pro259Arg) genetic polymorphism, total serum cobalamin and holo-TC levels, and disease onset in 70 patients with clinically diagnosed...
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