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Article

Abnormal development of mouse embryoid bodies lacking p27Kip1 cell cycle regulator.

Stem cells (Dayton, Ohio) - 1 Aug 2005

Bryja Vítezslav, Cajánek Lukás, Pacherník Jirí, Hall Anita C, Horváth Viktor, Dvorák Petr, Hampl Ales

Abstract excerpt

Cultures of three-dimensional aggregates of embryonic stem cells (ESCs) called embryoid bodies (EBs) provide a valuable system for analyzing molecular mechanisms that regulate differentiation of this unique cell type. Cyclin-dependent kinase inhibitor p27Kip1 (p27) becomes elevated during the differentiation of mouse ESCs (mESCs). In this study, various aspects of differentiation of EBs produced from normal and...

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Identifiers

PMID: 15941856
DOI: 10.1634/stemcells.2004-0174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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