Article
A randomized, placebo-controlled, double-blind trial on sulfadoxine-pyrimethamine alone or combined with artesunate or amodiaquine in uncomplicated malaria.
Tropical medicine & international health : TM & IH - 1 Jun 2005
Mockenhaupt Frank P, Ehrhardt Stephan, Dzisi Stephen Y, Teun Bousema J, Wassilew Nasstasja, Schreiber Jonas, Anemana Sylvester D, Cramer Jakob P, Otchwemah Rowland N, Sauerwein Robert W, Eggelte Teunis A, Bienzle Ulrich
Abstract excerpt
The therapeutic efficacy of sulfadoxine-pyrimethamine (SP) alone, SP plus amodiaquine (AQ), and SP plus artesunate (AS) was assessed in a randomized, placebo-controlled, and double-blind trial among 438 children with uncomplicated Plasmodium falciparum malaria in northern Ghana. Clinical and parasitological responses were monitored for 28 days following treatment; 86%, 98% and 97% of SP-, SP + AQ-, and SP +...
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