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Article

Artesunate plus sulfadoxine-pyrimethamine for uncomplicated malaria in Kenyan children: a randomized, double-blind, placebo-controlled trial.

Transactions of the Royal Society of Tropical Medicine and Hygiene - 1 Jan 2000

Obonyo Charles O, Ochieng Francis, Taylor Walter R J, Ochola Samuel A, Mugitu Kefas, Olliaro Piero, ter Kuile Feiko, Oloo Aggrey J

Abstract excerpt

Plasmodium falciparum has developed resistance to almost all routinely used antimalarial drugs. Sulfadoxine-pyrimethamine (SP) has replaced chloroquine as first-line treatment of uncomplicated malaria infection in Kenya but resistance to SP is already reported. The addition of artemisinin derivatives to SP may delay the development of drug resistance, improve cure rates, and reduce transmission. The efficacy and...

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Identifiers

PMID: 15307433
DOI: 10.1016/s0035-9203(03)80038-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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