Variation of hepatitis C virus following serial transmission: multiple mechanisms of diversification of the hypervariable region and evidence for convergent genome evolution.

doi:10.1099/0022-1317-80-3-717

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Article

Variation of hepatitis C virus following serial transmission: multiple mechanisms of diversification of the hypervariable region and evidence for convergent genome evolution.

The Journal of general virology - 1 Mar 1999

Casino C, McAllister J, Davidson F, Power J, Lawlor E, Yap P L, Simmonds P, Smith D B

Abstract excerpt

We have studied the evolution of hepatitis C virus (HCV) from a common source following serial transmission from contaminated batches of anti-D immunoglobulin. Six secondary recipients were each infected with virus from identifiable primary recipients of HCV-contaminated anti-D immunoglobulin. Phylogenetic analysis of virus E1/E2 gene sequences [including the hypervariable region (HVR)] and part of NS5B confirmed...

Topics

Adolescent
Adult
Aged
Amino Acid Sequence
Base Sequence
Blood Transfusion
Child
Drug Contamination
Evolution, Molecular
Female
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome, Viral

Hepacivirus

Hepatitis C

Humans

Infectious Disease Transmission, Vertical

Ireland

Male

Source

Open in PubMed

Identifiers

PMID: 10092012
DOI: 10.1099/0022-1317-80-3-717

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