Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Forced expression of PDX-1 gene makes hepatoma cells to acquire glucose-responsive insulin secretion while maintaining hepatic characteristic.

Cellular and molecular biology (Noisy-le-Grand, France) - 28 Feb 2015

Hashimoto H, Higuchi Y, Kawai K

Abstract excerpt

Evidence shows that forced expression of the PDX1 gene converts hepatoma cells, mouse liver epithelial cells (MLECs) and HepaRG cells, into insulin—producing cells, β—cells, or islets of Langerhans. However, no reports have investigated the characteristics of mouse or human hepat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Albumins
Share to Basic Helix-Loop-Helix Transcription Factors
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Transfer Techniques

Share to Glucokinase

Share to Glucose

Share to Hepatocytes

Share to Mice, Inbred C3H

Source

Identifiers

PMID: 25817342

Genes

PDX1
MAFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25817342-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Forced expression of PDX-1 gene makes hepatoma cells to acquire glucose-responsive insulin secretion while maintaining hepatic characteristic.PMID 25817342Read ↗

In vitro transdifferentiation of hepatoma cells into functional pancreatic cells.Semantic proximity Read ↗

Improvement of the therapeutic capacity of insulin-producing cells trans-differentiated from human liver cells using engineered cell sheet Semantic proximity Read ↗

Long-Term Correction of Diabetes in Mice by In Vivo Reprogramming of Pancreatic DuctsSemantic proximity Read ↗

Regulated Expression of pdx-1 Promotes In Vitro Differentiation of Insulin-Producing Cells From Embryonic Stem CellsSemantic proximity Read ↗

Exendin-4 Promotes Liver Cell Proliferation and Enhances the PDX-1-induced Liver to Pancreas Transdifferentiation ProcessSemantic proximity Read ↗

The Temporal and Hierarchical Control of Transcription Factors-Induced Liver to Pancreas TransdifferentiationSemantic proximity Read ↗

PDX-1 Induces Differentiation of Intestinal Epithelioid IEC-6 Into Insulin-Producing CellsSemantic proximity Read ↗

In vitro cultured islet-derived progenitor cells of human origin express human albumin in severe combined immunodeficiency mouse liver in vivo.Semantic proximity Read ↗

PDX-1 Protein Containing Its Own Antennapedia-Like Protein Transduction Domain Can Transduce Pancreatic Duct and Islet CellsSemantic proximity Read ↗

Differentiation of islet cells in long-term culture.Semantic proximity Read ↗

Sustained proliferation of PDX-1+ cells derived from human islets.Semantic proximity Read ↗

Signals from pancreatic mesoderm influence the expression of a pancreatic phenotype in hepatic stem-like cell line PHeSC-A2 in vitro: a preliminary study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.