Automated in situ measurement of cell‐specific antibody secretion and laser‐mediated purification for rapid cloning of highly‐secreting producers

Abstract excerpt

Cloning of highly-secreting recombinant cells is critical for biopharmaceutical manufacturing, but faces numerous challenges including the fact that secreted protein does not remain associated with the producing cell. A fundamentally new approach was developed combining in situ capture and measurement of individual cell protein secretion followed by laser-mediated elimination of all non- and poorly-secreting...

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