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Utilizing non-clonal CHO cell derived materials for preclinical studies of complex molecules

7 May 2025

Abstract excerpt

BACKGROUND: The use of non-clonal CHO cell derived materials for preclinical studies has been found to be a valuable approach to accelerate the development of monoclonal antibodies (mAbs) for first-in-human (FIH) studies. In a comprehensive study, we assessed the culture performance, productivity, and product quality of non-clonal cell lines compared with clonal cell lines expressing various biologic modalities...

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PMID: 40335959
DOI: 10.1186/s12896-025-00968-4

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