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Article

Peroxisome proliferator-activated receptor alpha gene variation influences age of onset and progression of type 2 diabetes.

Diabetes - 1 Feb 2005

Flavell David M, Ireland Helen, Stephens Jeffrey W, Hawe Emma, Acharya Jay, Mather Hugh, Hurel Steven J, Humphries Steve E

Abstract excerpt

Dysregulation of fatty acid metabolism is important in the pathogenesis of type 2 diabetes. Peroxisome proliferator-activated receptor (PPAR)alpha is a master regulator of fatty acid catabolism, and PPARalpha activators delay the onset of type 2 diabetes. We examined association between three PPARalpha gene polymorphisms (an A-->C variant in intron 1, the L162V variant, and the intron 7 G-->C variant) and age at...

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Identifiers

PMID: 15677519
DOI: 10.2337/diabetes.54.2.582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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