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Article

The aggregation kinetics of Alzheimer's beta-amyloid peptide is controlled by stochastic nucleation.

Protein science : a publication of the Protein Society - 1 Jul 2005

Hortschansky Peter, Schroeckh Volker, Christopeit Tony, Zandomeneghi Giorgia, Fändrich Marcus

Abstract excerpt

We report here a recombinant expression system that allows production of large quantities of Alzheimer's Abeta(1-40) peptide. The material is competent to dissolve in water solutions with "random-coil properties," although its conformation and factual oligomerization state are determined by the physico-chemical solution conditions. When dissolved in 50 mM sodium phosphate buffer (pH 7.4) at 37 degrees C, the...

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Identifiers

PMID: 15937275
DOI: 10.1110/ps.041266605
PMCID: PMC2253354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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