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Article

Phosphorylation of the Spi-B transcription factor reduces its intrinsic stability.

FEBS letters - 31 Dec 1999

Ray-Gallet D, Moreau-Gachelin F

Abstract excerpt

The Spi-B transcription factor is an Ets protein expressed in B lymphoid cells and closely related to the Spi-1/PU.1 oncoprotein. By mutational analysis, we showed that Spi-B is phosphorylated by casein kinase II in vitro on four serine residues. Mutation of these four serines to alanines prevented the phosphorylation of Spi-B in vivo, increased the ability of Spi-B to transactivate expression of a reporter gene...

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Source

Identifiers

PMID: 10618498
DOI: 10.1016/s0014-5793(99)01687-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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