Article
Characterization of the in vitro transcriptional activity of polymorphic alleles of the human monoamine oxidase-B gene.
Neuroscience letters - 1 Jan 2000
Costa-Mallen Paola, Kelada Samir N, Costa Lucio G, Checkoway Harvey
Abstract excerpt
The activity of monoamine oxidase-B (MAO-B) enzyme has a high degree of heritability, although no common genetic polymorphisms are present in the MAO-B coding region. The only known polymorphisms in MAO-B gene are a C-1,114T in the 5' region, a variable number of GT repeats in intron 2, and a G/A change in intron 13. The genetically determined differences in MAO-B activity among subjects most likely derive from...
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