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Article

A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes.

Current biology : CB - 7 Jun 2005

Dorer Russell K, Zhong Sheng, Tallarico John A, Wong Wing Hung, Mitchison Timothy J, Murray Andrew W

Abstract excerpt

The spindle checkpoint prevents chromosome loss by preventing chromosome segregation in cells with improperly attached chromosomes [1, 2 and 3]. The checkpoint senses defects in the attachment of chromosomes to the mitotic spindle [4] and the tension exerted on chromosomes by spindle forces in mitosis [5, 6 and 7]. Because many cancers have defects in chromosome segregation, this checkpoint may be required for...

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PMID: 15936280
DOI: 10.1016/j.cub.2005.05.020

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