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Article

Inducible expression of Runx2 results in multiorgan abnormalities in mice.

Journal of cellular biochemistry - 1 Feb 2011

He Nan, Xiao Zhousheng, Yin Tong, Stubbs Jason, Li Linheng, Quarles L Darryl

Abstract excerpt

Runx2 is a transcription factor controlling skeletal development, and is also expressed in extraskeletal tissues where its function is not well understood. Existing Runx2 mutant and transgenic mouse models do not allow the necessary control of Runx2 expression to understand its functions in different tissues. We generated conditional, doxycyline-inducible, triple transgenic mice...

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PMID: 21268087
DOI: 10.1002/jcb.22968
PMCID: PMC5079519

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