Article
Human B lymphoblast cell lines defective of Stat6 signaling produce high levels of proinflammatory cytokines IL-12, TNFalpha and IFNgamma.
International journal of oncology - 1 Feb 2004
Zhang Wen Jie, Koltun Walter A, Thompson Jennifer L, Tilberg Anna F, Galka Eva, Poritz Lisa S, Chorney Michael J
Abstract excerpt
Based on Stat6 gene knockout animal models, the Stat6 signaling pathway has been suggested to play a role in carcinogenesis and Th1/Th2 cytokine balance. Using a semiquantitative EMSA assay and EBV-transformed human B lymphoblast cell lines, we have previously identified three Stat6 activational phenotypes, termed as Stat6high, Stat6low, and Stat6null. A genetic mechanism has been proposed which determines the...
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