Article
Hyper-susceptibility of a fusidic acid-resistant mutant of Salmonella to different classes of antibiotics.
FEMS microbiology letters - 15 Jun 2005
Macvanin Mirjana, Hughes Diarmaid
Abstract excerpt
Fusidic acid resistance (Fus(R)) in Salmonella enterica serovar Typhimurium is caused by mutations in fusA, encoding elongation factor G (EF-G). Pleiotropic phenotypes are observed in Fus(R) mutants. Thus, the fusA1 allele (EF-G P413L) is associated with slow growth rate, reduced ppGpp and RpoS levels, reduced heme levels, and increased sensitivity to oxidative stress. The fusA1-15 allele, (EF-G P413L and T423I)...
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