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Article

Demonstration by burst-phase analysis of a robust folding intermediate in the FF domain.

Protein engineering, design & selection : PEDS - 1 Mar 2008

Jemth Per, Johnson Christopher M, Gianni Stefano, Fersht Alan R

Abstract excerpt

The role of intermediates in the folding reaction of single-domain proteins is a controversial issue. It was previously shown by different methods that an on-pathway intermediate is populated in the presence of sodium sulphate during the folding of the FF domain from HYPA/FBP11. Here we demonstrate using analysis of the amplitudes of kinetic traces that this burst-phase folding intermediate is present at...

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PMID: 18239073
DOI: 10.1093/protein/gzm091

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