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Mutational Analysis of Protein Folding Transition States: Phi Values.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022

Campos Luis Alberto

Abstract excerpt

The analysis of protein folding reactions by monitoring the kinetic effects of specifically designed single-point mutations, the so-termed phi-value analysis, has been a favorite technique to experimentally probe the mechanisms of protein folding. The idea behind phi-value analysis is that the effects that mutations have on the folding and unfolding rate constants report on the energetic/structural features of...

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PMID: 34845601
DOI: 10.1007/978-1-0716-1716-8_1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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