Article
Transition states and the meaning of Phi-values in protein folding kinetics.
Nature structural biology - 1 Sept 2001
Ozkan S B, Bahar I, Dill K A
Abstract excerpt
What is the mechanism of two-state protein folding? The rate-limiting step is typically explored through a Phi-value, which is the mutation-induced change in the transition state free energy divided by the change in the equilibrium free energy of folding. Phi-values ranging from 0 to 1 have been interpreted as meaning the transition state is denatured-like (0), native-like (1) or in-between. But there is no...
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