Article
Phi-value analysis and the nature of protein-folding transition states.
Proceedings of the National Academy of Sciences of the United States of America - 25 May 2004
Fersht Alan R, Sato Satoshi
Abstract excerpt
Phi values are used to map structures of protein-folding transition states from changes in free energies of denaturation (DeltaDeltaG(D-N)) and activation on mutation. A recent reappraisal proposed that Phi values for DeltaDeltaG(D-N) < 1.7 kcal/mol are artifactual. On discarding such derived Phi values from published studies, the authors concluded that there are no high Phi values in diffuse transition states,...
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