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Article

Characterization of the mismatch repair defect in the human lymphoblastoid MT1 cells.

Cancer research - 1 Jun 2005

Szadkowski Marta, Iaccarino Ingram, Heinimann Karl, Marra Giancarlo, Jiricny Josef

Abstract excerpt

Mutations in mismatch repair (MMR) genes predispose to hereditary nonpolyposis colon cancer. Those leading to truncated proteins bring about a MMR defect, but phenotypes of missense mutations are harder to predict especially if they do not affect conserved residues. Several systems capable of predicting the phenotypes of MMR missense mutations were described. We deployed one of these to study the MMR defect in...

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Identifiers

PMID: 15930269
DOI: 10.1158/0008-5472.CAN-05-0080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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