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Dimerization of MLH1 and PMS2 Limits Nuclear Localization of MutLα

16 Apr 2003

Abstract excerpt

DNA mismatch repair maintains genomic stability by detecting and correcting mispaired DNA sequences and by signaling cell death when DNA repair fails. The mechanism by which mismatch repair coordinates DNA damage and repair with cell survival or death is not understood, but it suggests the need for regulation. Since the functions of mismatch repair are initiated in the nucleus, we asked whether nuclear transport...

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Identifiers

PMID: 12697830
DOI: 10.1128/mcb.23.9.3320-3328.2003

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