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Article

The predicted truncation from a cancer-associated variant of the MSH2 initiation codon alters activity of the MSH2-MSH6 mismatch repair complex.

Molecular carcinogenesis - 1 Aug 2012

Cyr Jennifer L, Brown Graham D, Stroop Jennifer, Heinen Christopher D

Abstract excerpt

Lynch syndrome (LS) is caused by germline mutations in DNA mismatch repair (MMR) genes. MMR recognizes and repairs DNA mismatches and small insertion/deletion loops. Carriers of MMR gene variants have a high risk of developing colorectal, endometrial, ovarian, and other extracolonic carcinomas. We report on an ovarian cancer patient who carries a germline MSH2 c.1A>C variant which alters the translation...

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Source

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Identifiers

PMID: 21837758
DOI: 10.1002/mc.20838
PMCID: PMC3220760

Genes

MSH2
MSH6
MSH3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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