Article
Ionomycin downregulates beta-catenin/Tcf signaling in colon cancer cell line.
Carcinogenesis - 1 Nov 2005
Park Chi Hoon, Hahm Eun Ryeong, Lee Ju Hyung, Jung Kyung Chae, Rhee Ho Sung, Yang Chul Hak
Abstract excerpt
Functional activation of beta-catenin/Tcf signaling plays an important role in the early events in colorectal carcinogenesis. We examined the effect of ionomycin against beta-catenin/Tcf signaling in colon cancer cells. Reporter gene assay showed that ionomycin inhibited beta-catenin/Tcf signaling efficiently. In addition, the inhibition of beta-catenin/Tcf signaling by ionomycin in HEK293 cells transiently...
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