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Article

Neurotensin receptor 1 gene activation by the Tcf/β-catenin pathway is an early event in human colonic adenomas

19 Nov 2005

Abstract excerpt

Alterations in the Wnt/APC (adenomatous polyposis coli) signalling pathway, resulting in beta-catenin/T cell factor (Tcf)-dependent transcriptional gene activation, are frequently detected in familial and sporadic colon cancers. The neuropeptide neurotensin (NT) is widely distributed in the gastrointestinal tract. Its proliferative and survival effects are mediated by a G-protein coupled receptor, the NT1...

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PMID: 16299383
DOI: 10.1093/carcin/bgi269

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