Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibitory effect of nordihydroguaiaretic acid on β-catenin/Tcf signalling in β-catenin-activated cells.

Cell biochemistry and function - 1 Jan 2000

Park Seyeon, Lee Jihye

Abstract excerpt

Activated β-catenin/T-cell factor (Tcf) signalling plays a role in human carcinogenesis. We identified the inhibitory effect of nordihydroguaiaretic acid (NDGA) against β-catenin/Tcf signalling in β-catenin activated cells. NDGA inhibited the transcriptional activity of β-catenin/Tcf in HEK293 cells transiently transfected with a constitutively active mutant β-catenin gene. To investigate the inhibitory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axin Protein
Share to beta Catenin
Share to Cyclin D1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Electrophoretic Mobility Shift Assay

Share to Glycogen Synthase Kinase 3

Share to Glycogen Synthase Kinase 3 beta

Share to Proto-Oncogene Proteins c-myc

Share to TCF Transcription Factors

Source

Identifiers

PMID: 21264886
DOI: 10.1002/cbf.1713

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibitory effect of nordihydroguaiaretic acid on β-catenin/Tcf signalling in β-catenin-activated cells.PMID 21264886Read ↗

Inhibition of beta-catenin/Tcf signaling by flavonoids.Semantic proximity Read ↗

Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesisSemantic proximity Read ↗

Sulindac targets nuclear β-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell linesSemantic proximity Read ↗

Ionomycin downregulates beta-catenin/Tcf signaling in colon cancer cell line.Semantic proximity Read ↗

Green tea polyphenol EGCG suppresses Wnt/β-catenin signaling by promoting GSK-3β- and PP2A-independent β-catenin phosphorylation/degradation.Semantic proximity Read ↗

Analysis of the β‐Catenin/T Cell Factor Signaling Pathway in 36 Gastrointestinal and Liver Cancer CellsSemantic proximity Read ↗

Effect of nonsteroidal anti-inflammatory drugs on β-catenin protein levels and catenin-related transcription in human colorectal cancer cellsSemantic proximity Read ↗

The T cell factor/beta-catenin antagonist PKF115-584 inhibits proliferation of adrenocortical carcinoma cells.Semantic proximity Read ↗

Nitric oxide-donating aspirin inhibits β-catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear β-catenin–TCF associationSemantic proximity Read ↗

Neurotensin , a novel target of Wnt/β‐catenin pathway, promotes growth of neuroendocrine tumor cellsSemantic proximity Read ↗

Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5Semantic proximity Read ↗

Neurotensin receptor 1 gene activation by the Tcf/β-catenin pathway is an early event in human colonic adenomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.