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Article

Phenotype transformation of immortalized NCM460 colon epithelial cell line by TGF-β1 is associated with chromosome instability.

Molecular biology reports - 1 Oct 2016

Huang Chao, Wen Bin

Abstract excerpt

Transforming growth factor-β1 (TGF-β1) within tumor microenvironment has a pivotal function in cancer initiation and tumorigenesis, and hence this study was to observe the malignant transformation induced by TGF-β1 in an immortalized colon epithelial cell line NCM460 for better understanding the mechanisms of colon carcinogenesis. Immortalized colon epithelial cell line NCM460 was used as the model of this study,...

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Biomarkers, Tumor
Cell Transformation, Neoplastic
Chromosomal Instability
Colon
Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Epithelial-Mesenchymal Transition

Gene Expression Regulation, Neoplastic

Transforming Growth Factor beta1

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PMID: 27401062
DOI: 10.1007/s11033-016-4038-3

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