Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The crystal structure of Mlc, a global regulator of sugar metabolism in Escherichia coli.

The Journal of biological chemistry - 12 Aug 2005

Schiefner André, Gerber Kinga, Seitz Sabine, Welte Wolfram, Diederichs Kay, Boos Winfried

Abstract excerpt

Mlc from Escherichia coli is a transcriptional repressor controlling the expression of a number of genes encoding enzymes of the phosphotransferase system (PTS), including ptsG and manXYZ, the specific enzyme II for glucose and mannose PTS transporters. In addition, Mlc controls the transcription of malT, the gene of the global activator of the mal regulon. The inactivation of Mlc as a repressor is mediated by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Bacillus subtilis
Share to beta-Galactosidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carbohydrate Metabolism

Share to Databases, Protein

Share to Glucokinase

Share to Phosphoenolpyruvate Sugar Phosphotransferase System

Source

Identifiers

PMID: 15929984
DOI: 10.1074/jbc.M504215200

Genes

PTS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The crystal structure of Mlc, a global regulator of sugar metabolism in Escherichia coli.PMID 15929984Read ↗

Operator recognition by the ROK transcription factor family members, NagC and Mlc.Semantic proximity Read ↗

The MIG1 repressor from Kluyveromyces lactis: cloning, sequencing and functional analysis in Saccharomyces cerevisiae.Semantic proximity Read ↗

The ROK family regulator Rok7B7 pleiotropically affects xylose utilization, carbon catabolite repression, and antibiotic production in streptomyces coelicolor.Semantic proximity Read ↗

Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism.Semantic proximity Read ↗

Membrane localization itself but not binding to IICB is directly responsible for the inactivation of the global repressor Mlc in Escherichia coli.Semantic proximity Read ↗

Structural and functional characterization of the LldR from Corynebacterium glutamicum: a transcriptional repressor involved in L-lactate and sugar utilization.Semantic proximity Read ↗

DNA binding sites for the Mlc and NagC proteins: regulation of nagE, encoding the N-acetylglucosamine-specific transporter in Escherichia coli.Semantic proximity Read ↗

Glucose- and glucokinase-controlled mal gene expression in Escherichia coli.Semantic proximity Read ↗

A LacI-family regulator activates maltodextrin metabolism of Enterococcus faecium.Semantic proximity Read ↗

A novel regulatory role of glucose transporter of Escherichia coli: membrane sequestration of a global repressor Mlc.Semantic proximity Read ↗

Structure-based annotation of a novel sugar isomerase from the pathogenic E. coli O157:H7.Semantic proximity Read ↗

Negative regulation of the pts operon by Mlc: mechanism underlying glucose induction in Escherichia coli.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.