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Article

Operator recognition by the ROK transcription factor family members, NagC and Mlc.

Nucleic acids research - 1 Jan 2015

Bréchemier-Baey Dominique, Domínguez-Ramírez Lenin, Oberto Jacques, Plumbridge Jacqueline

Abstract excerpt

NagC and Mlc, paralogous members of the ROK family of proteins with almost identical helix-turn-helix DNA binding motifs, specifically regulate genes for transport and utilization of N-acetylglucosamine and glucose. We previously showed that two amino acids in a linker region outside the canonical helix-turn-helix motif are responsible for Mlc site specificity. In this work we identify four amino acids in the...

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Share to Amino Acid Motifs
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Share to Escherichia coli Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

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Share to Operator Regions, Genetic

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Identifiers

PMID: 25452338
DOI: 10.1093/nar/gku1265
PMCID: PMC4288165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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