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Article

A novel regulatory role of glucose transporter of Escherichia coli: membrane sequestration of a global repressor Mlc.

The EMBO journal - 16 Oct 2000

Tanaka Y, Kimata K, Aiba H

Abstract excerpt

External glucose stimulates transcription of several genes including ptsG encoding IICB(Glc), a membrane component of the phosphotransferase system (PTS), by relieving the negative regulation of a global repressor Mlc in Escherichia coli. We investigate here how glucose modulates Mlc action. The Mlc-mediated repression is eliminated by a ptsI mutation, while Mlc is constitutively active in a ptsG mutant. We show...

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Share to Cell Membrane
Share to Escherichia coli Proteins
Share to Gene Expression Regulation, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Phosphoenolpyruvate Sugar Phosphotransferase System

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Source

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Identifiers

PMID: 11032802
DOI: 10.1093/emboj/19.20.5344
PMCID: PMC314007

Genes

PTS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel regulatory role of glucose transporter of Escherichia coli: membrane sequestration of a global repressor Mlc.PMID 11032802Read ↗

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