Article
Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption.
Molecular and cellular biology - 1 Jun 2005
Pavlos Nathan J, Xu Jiake, Riedel Dietmar, Yeoh Joyce S G, Teitelbaum Steven L, Papadimitriou John M, Jahn Reinhard, Ross F Patrick, Zheng Ming H
Abstract excerpt
Rab3 proteins are a subfamily of GTPases, known to mediate membrane transport in eukaryotic cells and play a role in exocytosis. Our data indicate that Rab3D is the major Rab3 species expressed in osteoclasts. To investigate the role of Rab3D in osteoclast physiology we examined the skeletal arch...
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