Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure-function analysis of T4 RNA ligase 2.

The Journal of biological chemistry - 16 May 2003

Yin Shenmin, Ho C Kiong, Shuman Stewart

Abstract excerpt

Bacteriophage T4 RNA ligase 2 (Rnl2) exemplifies a polynucleotide ligase family that includes the trypanosome RNA-editing ligases and putative RNA ligases encoded by eukaryotic viruses and archaea. Here we analyzed 12 individual amino acids of Rnl2 that were identified by alanine scanning as essential for strand joining. We determined structure-activity relationships via conservative substitutions and examined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Alanine
Share to Lysine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutagenesis

Share to Nucleic Acid Conformation

Share to Structure-Activity Relationship

Share to Viral Proteins

Source

Identifiers

PMID: 12611899
DOI: 10.1074/jbc.M300817200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure-function analysis of T4 RNA ligase 2.PMID 12611899Read ↗

Bacteriophage T4 RNA ligase 2 (gp24.1) exemplifies a family of RNA ligases found in all phylogenetic domains.Semantic proximity Read ↗

Structure and mechanism of RNA ligase.Semantic proximity Read ↗

Mutational analysis of bacteriophage T4 RNA ligase 1. Different functional groups are required for the nucleotidyl transfer and phosphodiester bond formation steps of the ligation reaction.Semantic proximity Read ↗

DNA Ligases: Progress and ProspectsSemantic proximity Read ↗

T4 RNA ligase 2 truncated active site mutants: improved tools for RNA analysis.Semantic proximity Read ↗

Role of nucleotidyl transferase motif V in strand joining by chlorella virus DNA ligase.Semantic proximity Read ↗

Dual mechanisms whereby a broken RNA end assists the catalysis of its repair by T4 RNA ligase 2.Semantic proximity Read ↗

Crystal structure of eukaryotic DNA ligase-adenylate illuminates the mechanism of nick sensing and strand joining.Semantic proximity Read ↗

Structure-guided mutational analysis of the nucleotidyltransferase domain of Escherichia coli NAD+-dependent DNA ligase (LigA).Semantic proximity Read ↗

Characterisation and engineering of a thermophilic RNA ligase from Palaeococcus pacificus.Semantic proximity Read ↗

Structural and mutational analysis of archaeal ATP-dependent RNA ligase identifies amino acids required for RNA binding and catalysis.Semantic proximity Read ↗

The structure of the mammalian RNase H2 complex provides insight into RNA.NA hybrid processing to prevent immune dysfunction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.