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Article

Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs.

Journal of virology - 1 Jun 2005

Solórzano Alicia, Webby Richard J, Lager Kelly M, Janke Bruce H, García-Sastre Adolfo, Richt Jürgen A

Abstract excerpt

It has been shown previously that the nonstructural protein NS1 of influenza virus is an alpha/beta interferon (IFN-alpha/beta) antagonist, both in vitro and in experimental animal model systems. However, evidence of this function in a natural host has not yet been obtained. Here we investigated the role of the NS1 protein in the virulence of a swine influenza virus (SIV) isolate in pigs by using reverse...

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Identifiers

PMID: 15919908
DOI: 10.1128/JVI.79.12.7535-7543.2005
PMCID: PMC1143661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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