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Article

Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein.

Journal of virology - 1 Jul 2010

Hale Benjamin G, Steel John, Medina Rafael A, Manicassamy Balaji, Ye Jianqiang, Hickman Danielle, Hai Rong, Schmolke Mirco, Lowen Anice C, Perez Daniel R, García-Sastre Adolfo

Abstract excerpt

In 2009, a novel swine-origin H1N1 influenza A virus emerged. Here, we characterize the multifunctional NS1 protein of this human pandemic virus in order to understand factors that may contribute to replication efficiency or pathogenicity. Although the 2009 H1N1 virus NS1 protein (2009/NS1) is an effective interferon antagonist, we found that this NS1 (unlike those of previous human-adapted influenza A viruses)...

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Source

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Identifiers

PMID: 20444891
DOI: 10.1128/JVI.00081-10
PMCID: PMC2898253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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