Specific interaction between the nonphosphorylated form of RNA polymerase II and the TATA-binding protein.

doi:10.1016/0092-8674(92)90297-p

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Article

Specific interaction between the nonphosphorylated form of RNA polymerase II and the TATA-binding protein.

Cell - 29 May 1992

Usheva A, Maldonado E, Goldring A, Lu H, Houbavi C, Reinberg D, Aloni Y

Abstract excerpt

Fractionation of a transcription-competent HeLa cell extract on a column containing one copy of the heptamer repeat (YSPTSPS) present in the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II resulted in the loss of transcriptional activity. Fractionation of the extracts on columns containing mutations of the heptamer repeat was without effect. Such transcriptionally inactive extracts...

Topics

Amino Acid Sequence
Base Sequence
Blotting, Western
Cell Extracts
DNA-Binding Proteins
HeLa Cells
Humans
Molecular Sequence Data
Mutation
Peptide Fragments
Phosphorylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

RNA Polymerase II

Recombinant Proteins

Repetitive Sequences, Nucleic Acid

TATA-Box Binding Protein

Temperature

Transcription Factor TFIID

Source

Open in PubMed

Identifiers

PMID: 1591781
DOI: 10.1016/0092-8674(92)90297-p

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1591781-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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