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Article

Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis.

Molecular biology of the cell - 1 Aug 2005

Panaretakis Theocharis, Laane Edward, Pokrovskaja Katja, Björklund Ann-Charlotte, Moustakas Aristidis, Zhivotovsky Boris, Heyman Mats, Shoshan Maria C, Grandér Dan

Abstract excerpt

Here, we identified caspase-2, protein kinase C (PKC)delta, and c-Jun NH2-terminal kinase (JNK) as key components of the doxorubicin-induced apoptotic cascade. Using cells stably transfected with an antisense construct for caspase-2 (AS2) as well as a chemical caspase-2 inhibitor, we demonstrate...

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Identifiers

PMID: 15917298
DOI: 10.1091/mbc.e04-10-0862
PMCID: PMC1182319

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15917298-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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