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Article

BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure.

The Journal of biological chemistry - 24 Feb 2012

Singh Krishna K, Shukla Praphulla C, Quan Adrian, Desjardins Jean-François, Lovren Fina, Pan Yi, Garg Vinay, Gosal Sumandeep, Garg Ankit, Szmitko Paul E, Schneider Michael D, Parker Thomas G, Stanford William L, Leong-Poi Howard, Teoh Hwee, Al-Omran Mohammed, Verma Subodh

Abstract excerpt

The tumor suppressor breast cancer susceptibility gene 2 (BRCA2) plays an important role in the repair of DNA damage, and loss of BRCA2 predisposes carriers to breast and ovarian cancers. Doxorubicin (DOX) remains the cornerstone of chemotherapy in such individuals. However, it is often associated with cardiac failure, which once manifests carries a poor prognosis. Because BRCA2 regulates genome-wide stability...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22157755
DOI: 10.1074/jbc.M111.292664
PMCID: PMC3325595

Genes

BRCA2
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure.PMID 22157755Read ↗

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