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Article

Transcription of the protein kinase C-delta gene is activated by JNK through c-Jun and ATF2 in response to the anticancer agent doxorubicin.

Experimental & molecular medicine - 31 Dec 2008

Min Byong Wook, Kim Chang Gun, Ko Jesang, Lim Yoongho, Lee Young Han, Shin Soon Young

Abstract excerpt

Expression of protein kinase C-delta (PKCdelta) is up-regulated by apoptosis-inducing stimuli. However, very little is known about the signaling pathways that control PKCdelta gene transcription. In the present study, we demonstrate that JNK stimulates PKCdelta gene expression via c-Jun and ATF2 in response to the anticancer agent doxorubicin (DXR) in mouse lymphocytic leukemia L1210 cells. Luciferase reporter...

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Source

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Identifiers

PMID: 19116455
DOI: 10.3858/emm.2008.40.6.699
PMCID: PMC2679346

Genes

ATF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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