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Article

Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease.

Neurobiology of aging - 1 Jan 2000

Rademakers R, Sleegers K, Theuns J, Van den Broeck M, Bel Kacem S, Nilsson L-G, Adolfsson R, van Duijn C M, Van Broeckhoven C, Cruts M

Abstract excerpt

Malfunctioning of cyclin-dependent kinase 5 (CDK5) through aberrant proteolytic cleavage of its neuronal activators p35 and p39 is involved in neurodegeneration in Alzheimer's disease (AD) and other neurodegenerative brain diseases. By extensive genetic analysis of the genes encoding CDK5 (CDK5), p35 (CDK5R1) and p39 (CDK5R2), we excluded causal mutations in 70 familial early-onset AD patients. We performed an...

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Source

Identifiers

PMID: 15917097
DOI: 10.1016/j.neurobiolaging.2004.10.003

Genes

CDK5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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