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Article

Association of genetic variants in cyclin-dependent kinase 5 with Alzheimer's disease in a Saudi cohort.

Journal of Alzheimer's disease : JAD - 1 Apr 2026

Messaoudi Safia A, Alsaleh Abrar, AlSalem Lama A, Rameshbabu Saranya, Kumar Sachil, Assidi Mourad, Ouanes Khaled, Chayeb Vera, Zitouni Hedia, Almawi Wassim Y

Abstract excerpt

BackgroundCyclin-dependent kinase 5 (CDK5) plays a critical role in neuronal development, synaptic plasticity, and cytoskeletal regulation. Its dysregulation has been implicated in Alzheimer's disease (AD); however, supporting genetic evidence remains limited in Middle Eastern populations.ObjectiveThis study aimed to identify CDK5 genetic variants in a Saudi cohort with AD and evaluate their association with...

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Identifiers

PMID: 41848386
DOI: 10.1177/13872877261427358

Genes

CDK5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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