Article
Nonmyeloablative hematopoietic stem cell transplantation corrects the disease phenotype in the canine model of leukocyte adhesion deficiency.
Experimental hematology - 1 Jun 2005
Bauer Thomas R, Gu Yu-Chen, Tuschong Laura M, Burkholder Tanya, Bacher John D, Starost Matthew F, Donahue Robert E, Sokolic Robert A, Hickstein Dennis D
Abstract excerpt
OBJECTIVE: The aim of this study was to test a nonmyeloablative hematopoietic stem cell transplant regimen applicable to children with leukocyte adhesion deficiency (LAD) who have a histocompatible sibling donor by using the canine model of LAD, namely canine leukocyte adhesion deficiency or CLAD. METHODS: Thirteen CLAD pups received a hematopoietic stem cell transplant from a dog leukocyte antigen (DLA)-matched...
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